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574215
Sigma-AldrichD,L-Sulforaphane - CAS 4478-93-7 - Calbiochem
D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
More>>D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
Gamet-Payrastre, L., et al. 2000. Cancer Res.60, 1426. Yu, R., et al. 2000. J. Biol. Chem.275, 2322. Yu, R., et al. 1999. J. Biol. Chem.274, 27545. Barcelo, S., et al. 1998. Mutat. Res.402, 111. Maheo, K., et al. 1997. Cancer Res.57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 2399.
D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
Biological Information
Primary Target
Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
Purity
≥98% by UPLC
Physicochemical Information
Cell permeable
N
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem Certificates of Analysis
Title
Lot Number
574215
References
Reference overview
Gamet-Payrastre, L., et al. 2000. Cancer Res.60, 1426. Yu, R., et al. 2000. J. Biol. Chem.275, 2322. Yu, R., et al. 1999. J. Biol. Chem.274, 27545. Barcelo, S., et al. 1998. Mutat. Res.402, 111. Maheo, K., et al. 1997. Cancer Res.57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 2399.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.
Form
Slight yellow liquid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
4478-93-7
Chemical formula
C₆H₁₁NOS₂
Structure formula
Purity
≥98% by UPLC
Solubility
DMSO (20 mg/ml) or ethanol (10 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
Toxicity
Standard Handling
References
Gamet-Payrastre, L., et al. 2000. Cancer Res.60, 1426. Yu, R., et al. 2000. J. Biol. Chem.275, 2322. Yu, R., et al. 1999. J. Biol. Chem.274, 27545. Barcelo, S., et al. 1998. Mutat. Res.402, 111. Maheo, K., et al. 1997. Cancer Res.57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 2399.
