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219461 Cathepsin K, His•Tag®, Human, Recombinant, E. coli

Cathepsin K, His•Tag®, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

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219461
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Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
219461-25UG
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      		 Plastic ampoule 25 μg
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      Description
      OverviewCathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag® sequence.
      Note: 1 mU = 1 milliunit.
      Catalogue Number219461
      Brand Family Calbiochem®
      References
      ReferencesDelaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504.
      Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231.
      Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380.
      Hou, W.S., et al. 2003. Biol. Chem. 384, 891.
      Product Information
      CAS number94716-09-3
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
      EC number3.4.22.38
      FormLiquid
      FormulationIn 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.
      Quality LevelMQ100
      Biological Information
      Purity≥95% by SDS-PAGE
      Specific Activity≥900 mU/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Global Trade Item Number
      Catalogue Number GTIN
      219461-25UG 04055977218442