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03-34-0051 Calpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1
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03-34-0051
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117591-20-5C₂₀H₃₀N₂O₄

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      03-34-0051-25MG
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          03-34-0051-5MG
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              Description
              OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
              Catalogue Number03-34-0051
              Brand Family Calbiochem®
              SynonymsBenzyloxycarbonylleucyl-norleucinal
              References
              ReferencesLee, M.S., et al. 2000. Nature 405, 360.
              Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
              Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
              Shiba, E., et al. 1996. Anticancer Res. 16, 773.
              Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
              Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
              Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
              Product Information
              CAS number117591-20-5
              ATP CompetitiveN
              FormWhite to off-white solid
              Hill FormulaC₂₀H₃₀N₂O₄
              Chemical formulaC₂₀H₃₀N₂O₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
              Biological Information
              Primary TargetCalpain-1
              Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
              Purity≥94% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Leu-Nle-CHO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              03-34-0051-100MG 04055977206838
              03-34-0051-25MG 04055977206845
              03-34-0051-5MG 04055977206852

              Documentation

              Calpeptin - CAS 117591-20-5 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Calpeptin - CAS 117591-20-5 - Calbiochem Certificates of Analysis

              TitleLot Number
              03-34-0051

              References

              Reference overview
              Lee, M.S., et al. 2000. Nature 405, 360.
              Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
              Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
              Shiba, E., et al. 1996. Anticancer Res. 16, 773.
              Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
              Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
              Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

              Citations

              Title
            • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
            • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
              		•
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision08-October-2007 JSW
              SynonymsBenzyloxycarbonylleucyl-norleucinal
              DescriptionA cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
              FormWhite to off-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number117591-20-5
              Chemical formulaC₂₀H₃₀N₂O₄
              Peptide SequenceZ-Leu-Nle-CHO
              Structure formulaStructure formula
              Purity≥94% by HPLC
              SolubilityDMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
              Toxicity Standard Handling
              ReferencesLee, M.S., et al. 2000. Nature 405, 360.
              Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
              Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
              Shiba, E., et al. 1996. Anticancer Res. 16, 773.
              Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
              Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
              Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
              Citation
            • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
            • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
              		•