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227016 CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist

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227016
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
445479-97-0C₂₈H₃₄F₃N₅O₄S

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227016-5MG
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      Description
      OverviewA cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
      Catalogue Number227016
      Brand Family Calbiochem®
      Synonyms2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
      References
      ReferencesCherney, R.J., et al. 2008. J. Med. Chem. 51, 721.
      Product Information
      CAS number445479-97-0
      FormWhite solid
      Hill FormulaC₂₈H₃₄F₃N₅O₄S
      Chemical formulaC₂₈H₃₄F₃N₅O₄S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC (racemic mixture)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      227016-5MG 04055977200553

      Documentation

      CCR2 Antagonist - CAS 445479-97-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CCR2 Antagonist - CAS 445479-97-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      227016

      References

      Reference overview
      Cherney, R.J., et al. 2008. J. Med. Chem. 51, 721.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2011 JSW
      Synonyms2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
      DescriptionA cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number445479-97-0
      Chemical formulaC₂₈H₃₄F₃N₅O₄S
      Structure formulaStructure formula
      Purity≥97% by HPLC (racemic mixture)
      SolubilityDMSO (60 mg/ml) or Ethanol (6 mg/ml). Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCherney, R.J., et al. 2008. J. Med. Chem. 51, 721.