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SCT059 BioTracker™ TiY Vimentin Live Cell Dye

Live cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs.

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SCT059
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT059
      DescriptionBioTracker™ TiY Vimentin Live Cell Dye
      OverviewVimentin is an intermediate filament protein which is upregulated in cells undergoing epithelial-to-mesenchymal transition (EMT), and hence is commonly used an EMT marker. Tumor initiating cells (TICs) have been implicated in clinical relapse and metastasis of a variety of epithelial cancers, including lung cancer.

      BioTracker TiY Vimentin is a live cell fluorescent dye that selectively stains TICs over differentiated tumor cells or normal cells. TiY can be used for visualization and enrichment of functionally active TICs from patient tumors. TiY displays better selectivity for tumorigenic cells than a CD166 antibody and can be used for TiY-staining-based cell sorting for TICs in various types of cancer (lung, CNS, melanoma, breast, renal, ovarian, colon and prostate cancer). At high concentrations, TiY shows selective anti-TIC activity over non-TIC and normal tissue cells.

      Spectral Properties
      Absorbance: 553 nm
      Emission: 573 nm

      References
      Lee Y et al. Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2851-2854.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 541.87 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker TiY Vimentin Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT059 04054839736346