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178223
Sigma-AldrichAntipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.
More>>Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Effective concentration: 1-100 µM.
Catalogue Number
178223
Brand Family
Calbiochem®
References
References
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23. Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385 Umezawa, H. 1976. Methods Enzymol.55, 678. Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
trypsin-like serine proteases, papain, and some cysteine proteases
Primary Target IC<sub>50</sub>
300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
Purity
≥97% by HPLC
Physicochemical Information
Cell permeable
N
Safety Information according to GHS
RTECS
YV9350800
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Global Trade Item Number
Catalogue Number
GTIN
178223-10MG
04055977223118
Documentation
Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem SDS
Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem Certificates of Analysis
Title
Lot Number
178223
References
Reference overview
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23. Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385 Umezawa, H. 1976. Methods Enzymol.55, 678. Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
25-September-2014 JSW
Description
A reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
Form
White powder
CAS number
37682-72-7
RTECS
YV9350800
Chemical formula
C₂₇H₄₄N₁₀O₆ · 2HCl
Purity
≥97% by HPLC
Solubility
H₂O (1 mg/ml) or DMSO (5 mg/ml)
Storage
Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Toxicity
Standard Handling
References
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23. Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385 Umezawa, H. 1976. Methods Enzymol.55, 678. Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
