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MABC1166 Anti-iASPP Antibody, clone LX128.5

Anti-iASPP Antibody, clone LX128.5 is an antibody against iASPP for use in Immunohistochemistry (Paraffin).

Anti-iASPP Antibody, clone LX128.5 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI UniProt Number: Q8WUF5
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MABC1166
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC1166
      DescriptionAnti-iASPP Antibody, clone LX128.5
      Alternate Names
      • RelA-associated inhibitor
      • Inhibitor of apoptosis-stimulating protein of p53
      • Inhibitor of ASPP protein
      • NF-kB-interacting protein 1
      • PPP1R13B-like protein
      • Protein iASPP
      Background InformationRelA-associated inhibitor (UniProt Q8WUF5; also known as Inhibitor of apoptosis-stimulating protein of p53, Inhibitor of ASPP protein, NF-kB-interacting protein 1, PPP1R13B-like protein, Protein iASPP) is encoded by the PPP1R13L (also known as IASPP, NKIP1, PPP1R13BL, RAI) gene (Gene ID 10848) in human. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) belongs to the ASPP family of proteins (ASPP1, ASPP2, and iASPP) characterized by their ankyrin repeats (a.a. 659-691 & 692-724 in iASPP), SH3 domain (a.a. 758-820 in iASPP), and proline-rich (a.a. 54-602 in iASPP) sequences. iASPP is expressed at intercalated discs in post-mitotic cardiomyocytes, where it interacts with desmoplakin and desmin in cardiomyocytes to help maintain the integrity of desmosomes and intermediate filament networks. Desmosomes are anchoring junctions found in cells that endure physical stress such as cardiac myocytes or skin keratinocytes. Mutations of genes coding desmosome components, including IASPP/PPP1R13L, are found in human patients suffering from cardiomyopathy and in animal models of cardiomyopathy. iASPP deficiency caused by spontaneous mutation has been reported to be linked to a lethal autosomal recessive cardiomyopathy in Poll Hereford calves and Wa3 mice. iASSP-deficient mice with exon 8 deletion display features of arrhythmogenic right ventricular cardiomyopathy (ARVC) and die of sudden cardiac death.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-iASPP Antibody, clone LX128.5 is an antibody against iASPP for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A representative lot immunostained intercalated discs in myocardial sections from adult wild-type, but not iASPP-deficient (iASPPΔ8/Δ8) mice (Notari, M., et al. (2015). Proc. Natl. Acad. Sci. U. S. A. 112(9):E973-E981).
      Note: iASPP is expressed at intercalated discs. To prepare heart tissue sections for iASPP staining, it is important to cut the tissues at an angle parallel to the plane of the intercalated discs.
      Biological Information
      ImmunogenSynthetic linear peptide corresponding to a sequence from the N-terminal region of human iASPP.
      EpitopeN-terminal region.
      CloneLX128.5
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone LX128.5 immunostained intercalated discs in myocardial sections from wild-type, but not iASPP-deficient (iASPPΔ8/Δ8) adult mice (Notari, M., et al. (2015). Proc. Natl. Acad. Sci. U. S. A. 112(9):E973-E981).
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPP1R13L
      • IASPP
      • NKIP1
      • PPP1R13BL
      • RAI
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight89.09 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in mouse heart tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected iASPP in mouse heart tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC1166 04055977334265