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MABS1929-25UG Anti-hLYVE-1 Antibody, clone 8C

Anti-hLYVE-1, clone 8C, Cat. No. MABS1929, is a mouse monoclonal antibody that detects Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) and has been tested for use in Flow Cytometry, Immunocytochemistry, and Western Blotting.

Anti-hLYVE-1 Antibody, clone 8C MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: LYVE1, CRSBP1, HAR, XLKD1, UNQ230/PRO263 UniProt Number: Q9Y5Y7
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MABS1929-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, ICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1929-25UG
      DescriptionAnti-hLYVE-1 Antibody, clone 8C
      Alternate Names
      • Lymphatic vessel endothelial hyaluronic acid receptor 1
      • Cell surface retention sequence-binding protein 1
      • CRSBP-1
      • Extracellular link domain-containing protein 1
      • Hyaluronic acid receptor
      Background InformationLymphatic vessel endothelial hyaluronic acid receptor 1 (UniProt: Q9Y5Y7; LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1,Extracellular link domain-containing protein 1,Hyaluronic acid receptor) is encoded by the LYVE1 (also known as CRSBP1, HAR, XLKD1,UNQ230/PRO263) gene (Gene ID: 10894) in human. LYVE-1 is a disulfide-linked, homodimeric, single-pass type I membrane protein that undergoes ligand-dependent internalization and recycling at the cell surface.  It serves as a ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane.  It is mainly expressed in endothelial cells lining lymphatic vessels. It is expressed on both the luminal and basolateral surfaces of lymphatic endothelium. It is reported to mediate the uptake of intermediate and high molecular weight hyaluronan (HA) and serves as a low affinity receptor for HA-induced lymphoangiogenesis. It also controls the entry and/or migration of leukocytes in lymphatic vessels. The capacity of LYVE-1 to bind HA is based on a receptor distribution and organization of the glycosaminoglycans. (Ref.: Lawrence, W et al. (2016). J Biol Chem. 291(15): 8014 8030).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-hLYVE-1, clone 8C, Cat. No. MABS1929, is a mouse monoclonal antibody that detects Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) and has been tested for use in Flow Cytometry, Immunocytochemistry, and Western Blotting.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunocytochemistry Analysis: A representative lot detected hLYVE-1 in Immunocytochemistry applications (Lawrance, W., et. al. (2016). J Biol Chem. hLYVE-1; Banerji, S., et. al. (1999). J Cell Biol. 144(4):789-801).

      Western Blotting Analysis: A representative lot detected hLYVE-1 in Western Blotting applications (Banerji, S., et. al. (1999). J Cell Biol. 144(4):789-801; Banerji, S., et. al. (2016). J Biol Chem. 291(48):25004-25018).

      Flow Cytometry Analysis: A representative lot detected hLYVE-1 in Flow Cytometry applications (Lawrance, W., et. al. (2016). J Biol Chem. hLYVE-1; Banerji, S., et. al. (2016). J Biol Chem. 291(48):25004-25018).
      Biological Information
      ImmunogenA recombinant fragment corresponding to the ectodomain (1-232) region of human LYVE-1.
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 8C detects Lymphatic vessel endothelial hyaluronic acid receptor 1. It targets an epitope within the ectodomain region.
      IsotypeIgG1
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • LYVE1
      • CRSBP1
      • HAR
      • XLKD1
      • UNQ230/PRO263
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~60 kDa observed; 35.21 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in lysates from wild-type and LYVE-1 transfected HEK293T cells.

      Western Blotting Analysis: 2 ug/mL of this antibody detected LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1) in lysate from wild-type and LYVE transfected HEK293T cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1929-25UG 04054839543678