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ABC849 Anti-ZIP-1 Antibody

Anti-ZIP-1 Antibody detects level of ZIP-1 & has been published & validated for use in ZIP-1.

Anti-ZIP-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SLC39A1, IRT1, ZIP1, ZIRTL UniProt Number: Q9NY26
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ABC849
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC849
      DescriptionAnti-ZIP-1 Antibody
      Alternate Names
      • Zinc transporter ZIP1
      • Solute carrier family 39 member 1
      • Zinc-iron-regulated transporter-like
      • Zrt- and Irt-like protein 1
      • ZIP-1
      • hZIP1
      Background InformationZinc transporter ZIP1, also known as Solute carrier family 39 member 1 or Zinc-iron-regulated transporter-like or Zrt- and Irt-like protein 1 (ZIP-1 or hZIP1), and encoded by the gene name SLC39A1 or IRT1 or ZIP1 or ZIRTL, is responsible to the rapis uptake and accumulation of physiologically effective zinc in prostate cells. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to downregulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ZIP-1 Antibody detects level of ZIP-1 & has been published & validated for use in ZIP-1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected ZIP-1 in human kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the N-terminus of human ZIP-1.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody is predicted to not cross-react with other ZIP family members.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SLC39A1
      • IRT1
      • ZIP1
      • ZIRTL
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Mouse kidney tissue lysate.

      Western Blotting Analysis: 2 μg/mL of this antibody detected ZIP-1 in Mouse kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC849 04053252943973