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MAB2627 Anti-VCAM-1 (CD106) Antibody, clone 6C7.1

Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH.

Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: VCAM1, VCAM-1, CD106, V-CAM 1, INCAM-100, L1CAM UniProt Number: P29533
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MAB2627
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IP, ICC, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2627
      DescriptionAnti-VCAM-1 (CD106) Antibody, clone 6C7.1
      Alternate Names
      • vascular cell adhesion molecule 1
      • vascular cell adhesion protein 1
      • CD106 antigen
      Background InformationVascular cell adhesion protein 1 (VCAM-1) is a cell surface adhesion molecule belonging to the immunoglobulin cell-cell adhesion receptor family and is comprised of seven Ig-like C2-type domains. VCAM-1 is a crucial component in cell-cell recognition and seems to be involved in cellular adhesion between endothelial cells and leukocytes. It has a regulatory role for both signal transduction and adhesion through its interaction with leukocyte beta-1 integrin VLA4, an interaction that is potentially involved in immune and inflammatory emigration responses of leukocytes. Studies have shown upregulation of VCAM-1 to be critical in responding to inflammatory diseases such as atherosclerosis. VCAM-1 is primarily expressed in endothelial cells and is expressed as two known isoforms found within the cell membrane. Isoform 1 functions as a single-pass type 1 membrane protein, while Isoform 2 acts as a GPI-anchor.
      References
      Product Information
      FormatPurified
      Control
      • Mouse bone marrow cells
      PresentationPurified rat monoclonal IgG1κ in buffer containing PBS without preservative.
      Quality LevelMQ100
      Applications
      ApplicationAnti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A previous lot was used by independent laboratory in IH. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)

      Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)
      Biological Information
      ImmunogenMouse endothelial cells
      Clone6C7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VCAM1
      • VCAM-1
      • CD106
      • V-CAM 1
      • INCAM-100
      • L1CAM
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

      SUBUNIT STRUCTURE: Binds to ECMV-D capsid proteins and acts as a receptor for this virus.

      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.

      Isoform 2: Cell membrane; Lipid-anchor › GPI-anchor.

      TISSUE SPECIFICTY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

      PTM: The GPI-anchor is located on position 319 of isoform 2.

      SEQUENCE SIMILARITIES: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
      Molecular Weight81 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in mouse bone marrow cells.

      Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB2627 04053252376603

      Documentation

      Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 Certificates of Analysis

      TitleLot Number
      Anti-VCAM-1 (CD106), clone 6C7.1 - 2210373 2210373
      Anti-VCAM-1 (CD106), clone 6C7.1 - 2318825 2318825
      Anti-VCAM-1 (CD106), clone 6C7.1 - 3180442 3180442
      Anti-VCAM-1 (CD106), clone 6C7.1 - 3585809 3585809
      Anti-VCAM-1 (CD106), clone 6C7.1 - 3837163 3837163
      Anti-VCAM-1 (CD106), clone 6C7.1 - 4096893 4096893
      Anti-VCAM-1 (CD106), clone 6C7.1 - NRG1803626 NRG1803626
      Anti-VCAM-1 (CD106), clone 6C7.1 -2515424 2515424
      Anti-VCAM-1 (CD106), clone 6C7.1 -2786348 2786348
      Anti-VCAM-1 (CD106), clone 6C7.1 Monoclonal Antibody 3020533