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MAB4343-25UG Anti-Sox-2 (Mouse Monoclonal)

Anti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.

Anti-Sox-2 (Mouse Monoclonal) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: SOX2, ANOP3, MGC2413, MCOPS3 UniProt Number: P48431
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MAB4343-25UG
25 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, IHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4343-25UG
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Sox-2 (Mouse Monoclonal)
      Background InformationSox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
      References
      Product Information
      FormatPurified
      PresentationPurified Immunoglobulin by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenRecombinant GST Fusion protein.
      Clone6F1.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
      Gene Symbol
      • SOX2
      • ANOP3
      • MGC2413
      • MCOPS3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).
      SIZE: 317 amino acids; 34310 Da
      SUBCELLULAR LOCATION: Nucleus.
      DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.
      SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mouse Embryonic Stem Cells
      • Neural Stem Cells
      • Induced Pluripotent Stem Cells
      Molecular Weight~34 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceTested
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB4343-25UG 04054839342721