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MABT157 Anti-Parvin alpha Antibody, clone 7E2.1

This Anti-Parvin alpha Antibody, clone 7E2.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Parvin alpha.

Anti-Parvin alpha Antibody, clone 7E2.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: PARVA, MXRA2 UniProt Number: Q9NVD7
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MABT157
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT157
      DescriptionAnti-Parvin alpha Antibody, clone 7E2.1
      Alternate Names
      • Alpha-parvin
      • α-Parvin
      • a-Parvin
      • topaxin
      • CH-ILKBP
      • Calponin-like integrin-linked kinase-binding protein
      • Matrix-remodeling-associated protein 2
      Background InformationThe protein named α-Parvin or Parvin, or Actopaxin, or Calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or Matrix-remodeling-associated protein 2 (MXRA2), and encoded by the gene PARVA/MXRA2, is a critical adhesion coupling protein involved in many systems including sarcomere organization, smooth muscle contraction, cardiovascular development, angiogenesis, actin cytoskeleton organization and the establishment of cell polarity, adhesion, spreading and migration. α-Parvin is required for the adhesion of smooth muscle cell to endothelial cells during blood vessel development and for the formation of lamellipodia and ciliogenesis. α-Parvin is localized to the cell junction and focal adhesions. The protein is peripheral membrane protein located on the cytoplasmic side of the cell membranes and interacts with the cytoskeleton in the cytoplasm. In muscle cells it is associated with the Z line of the sarcomere. α-Parvin is expressed many tissues including muscle, kidney and liver.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Parvin alpha Antibody, clone 7E2.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Parvin alpha.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution and a 1:50 dilution from a representative lot detected Parvin alpha in human kidney and skeletal muscle tissues, respectively.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Parvin.
      Clone7E2.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PARVA
      • MXRA2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~42 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human heart tissue.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Parvin alpha in 200 µg of human heart tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT157 04053252939815