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AB939-I Anti-Pancreatic Polypeptide

Anti-Pancreatic Polypeptide Antibody, Cat. No. AB939-I, is a highly specific rabbit polyclonal antibody that targets Pancreatic polypeptide and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Pancreatic Polypeptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: PPY, PNP UniProt Number: P01298
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AB939-I
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB939-I
      DescriptionAnti-Pancreatic Polypeptide
      Alternate Names
      • Pancreatic hormone
      • PP
      • Obinepitide
      Background InformationPancreatic polypeptide (UniProt: P01298; also known as PP, Obinepitide, Pancreatic prohormone) is encoded by the PPY (also known as PNP) gene (Gene ID: 5539) in human. Pancreatic polypeptide is a member of the neuropeptide Y family and is secreted protein that is produced by PP cells in the pancreatic islets of Langerhans. It is synthesized with a signal peptide (aa 1-29), which is subsequently cleaved off. It acts as a regulator of pancreatic and gastrointestinal functions. Two isoforms of pancreatic polypeptide have been described that are generated by alternative splicing. Pancreatic polypeptide release is functionally associated with increased satiety, delayed gastric emptying, inhibition of gallbladder motility, and regulation of energy expenditure. Its deficiency is observed in cases of pancreatic resection and chronic pancreatitis and is associated with significant reduction in PP cell mass and abnormally high hepatic glucose production even in the presence of endogenous insulin. (Ref.: Maxwell, J et al. (2014). Pancreas 43(4); 651-656).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Pancreatic Polypeptide Antibody, Cat. No. AB939-I, is a highly specific rabbit polyclonal antibody that targets Pancreatic polypeptide and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 1:2,000 dilution from a representative lot detected Pancreatic Polypeptide in 10 µg of human pancreas tissue lysate.

      Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Pancreatic Polypeptide in human pancreas tissue sections.

      Immunocytochemistry Analysis (ICC): A 1:500 dilution from a representative lot detected Pancreatic Polypeptide in TGP52 cell line.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 36 amino acids the internal region of human pancreatic polypeptide.
      Epitopecytoplasmic domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects both isoforms of human pancreatic polypeptide. It targets an epitope within 36 amino acids from the internal region.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rhesus Macaque based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPY
      • PNP
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~11 and ~20 kDa observed for isoforms 1 and 2; 10.45 and 18.79 kDa calculated for isoforms 1 and 2. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PANC-1 cell lysate.

      Western Blotting Analysis: 1:2,000 dilution of this antibody detected Pancreatic Polypeptide in 10 µg of PANC-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB939-I 04054839399756