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MABF2338-100UG Anti-PVR (CD155) Antibody, clone TX24

Anti-PVR (CD155), clone TX24, Cat. No. MABF2338, is a mouse monoclonal that detects PVR (CD155) and has been tested for use in Flow Cytometry and Inhibition/Function Analysis.

MABF2338-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF2338-100UG
      DescriptionAnti-PVR (CD155) Antibody, clone TX24
      Alternate Names
      • Poliovirus receptor
      • Nectin-like protein 5
      • NECL-5
      • CD155
      Background InformationPoliovirus receptor (UniProt: P15151; also known as Nectin-like protein 5, NECL-5, CD155) is encoded by the PVR (also known as PVS) gene (Gene ID: 5817) in human. CD155 is a single-pass type I, N-glycosylated, membrane protein that mediates NK cell adhesion and triggers NK cell effector functions. It is ubiquitously expressed in various tissues and many human tumors are reported to significantly upregulate its expression. It binds two different NK cell receptors: CD96 and CD226 and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and the target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. CD155 serves as a receptor for poliovirus and may play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with dynein light chain Tctex-type 1 (DYNLT1). It is synthesized with a signal peptide (aa 1-20), which is subsequently cleaved off to generate the mature form that contains an extracellular domain (aa 21-343), a transmembrane domain (aa 344-367), and a cytoplasmic domain (aa 368-417). It contains two Ig-like C2 type domains (aa 145-237 and 233-328), and an Ig-like V-type domain that is shown to be necessary and sufficient for virus binding and uptake. CD155 also has one the immunoreceptor tyrosine-based inhibitor motif (ITIM; aa 396-401) that when phosphorylated by Src kinases binds to the SH2 domain of several SH2-containing phosphatases. (Ref.: Tahara-Hanaoka, S., et al. (2004). International Immunology, Vol. 16, No. 4, pp. 533-538; Iguchi-Manaka, A., et al. (2016). PLoS One. 11(4); e0152982).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PVR (CD155), clone TX24, Cat. No. MABF2338, is a mouse monoclonal that detects PVR (CD155) and has been tested for use in Flow Cytometry and Inhibition/Function Analysis.
      Key Applications
      • Flow Cytometry
      • Inhibits Activity/Function
      Application NotesFlow Cytometry Analysis: A representative lot detected PVR (CD155) in Flow Cytometry applications (Tahara-Hanaoka, S., et. al. (2004). Int Immunol. 16(4):533-8).

      Inhibits Activity/Function: A representative lot partially inhibited the cytotoxicity mediated by T and NK cells. (Tahara-Hanaoka, S., et. al. (2004). Int Immunol. 16(4):533-8).
      Biological Information
      ImmunogenA recombinant fragment corresponding to 323 amino acids from the extracellular domain of human Poliovirus receptor (CD155).
      Epitopeextracellular domain
      CloneTX24
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone TX24 is mouse monoclonal antibody that detects human Poliovirus receptor (CD155). It targets an epitope within the extracellular domain.
      IsotypeIgG2aλ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PVR
      • PVS
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight45.30 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in U937 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected PVR (CD155) in one million U937 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2338-100UG 04061841078166

      Documentation

      Anti-PVR (CD155) Antibody, clone TX24 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PVR (CD155) Antibody, clone TX24 Certificates of Analysis

      TitleLot Number
      Anti-PVR (CD155), clone TX24 - Q3308343 Q3308343

      References

      Reference overviewPub Med ID
      Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
      Tahara-Hanaoka, S; Shibuya, K; Onoda, Y; Zhang, H; Yamazaki, S; Miyamoto, A; Honda, S; Lanier, LL; Shibuya, A
      Int Immunol  16  533-8  2004

      Show Abstract       		15039383 15039383