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ABN96 Anti-Neurexin3 Antibody

Detect Neurexin3 using this Anti-Neurexin3 Antibody validated for use in WB, IH.

Anti-Neurexin3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: NRXN3, C14orf60, KIAA0743 UniProt Number: Q9Y4C0
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ABN96
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN96
      DescriptionAnti-Neurexin3 Antibody
      Alternate Names
      • Neurexin-3-alpha
      • Neurexin III-alpha
      Background InformationNeurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion. (Missler, M., et al. (1998) 14(1):20-26) Antibody Anti-neurexin 3 alpha (ABN96) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human neurexin 3 alpha (Uniprot Q9Y4C0). Although the theoretical full length of Neurexin 1alpha is 180 kDa, the protein detected in human brain lysates may show a band around 180 kDa and additional bands around 40-55 kDa as a possible result of the posttranslational processing previously reported.
      References
      Product Information
      FormatAffinity Purified
      Control
      • PC12 cell lysate.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Neurexin3 using this Anti-Neurexin3 Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Neurexin-3 in normal mouse brain tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Neurexin-3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNeurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.
      Gene Symbol
      • NRXN3
      • C14orf60
      • KIAA0743
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

      SUBUNIT STRUCTURE: The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      Molecular Weight~180 kDa observed. UniProtKB/Swiss-Prot Q9Y4C0 (NRX3A_HUMAN) states 2 isoforms due to alternative promoter usage and alternative splicing at a molecular weight of ~181 kDa and ~117 kDa, with several beta isoforms at a molecular weight 70 kDa, 51 kDa, 47 kDa, and 44 kDa. Additional bands may also be observed around 40-55 kDa as a possible result of the posttranslational processing.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in PC12 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Neurexin-3 in 10 µg of PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN96 04053252421181