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MAB3315 Anti-MMP-7 Antibody, clone 141-7B2

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MAB3315
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB3315
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MMP-7 Antibody, clone 141-7B2
      Alternate Names
      • Matrilysin
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease-free bovine serum albumin.
      Quality LevelMQ100
      Applications
      ApplicationAnti-MMP-7 Antibody, clone 141-7B2 is an antibody against MMP-7 for use in ELISA, WB, IH(P).
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunoblotting: 10 μg/mL Molecular weight band around 30kDa.

      Immunohistochemistry on paraffin-embedded tissue sections: 4-20 μg/mL

      EIA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRectal carcinoma (SW837) cells.
      Clone141-7B2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody specifically reacts with precursor form of human MMP-7. Does not cross-react with the active forms of human MMP-7 and human MMP-1, 2, 3, 8, 9 and 13.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
      Gene Symbol
      • MMP7
      • MPSL1
      • matrin
      • MMP-7
      • PUMP-1
      • Matrin
      • PUMP1
      • EC 3.4.24.23
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
      COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.
      SIZE: 267 amino acids; 29677 Da
      DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      SIMILARITY: Belongs to the peptidase M10A family.
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Manufactured by Daiichi Fine Chemical Co., Ltd
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MAB3315 08436037125409