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ABN335 Anti-LGI2 Antibody

Detect the LGI2 protein using this Anti-LGI2 validated for use in WB.

Anti-LGI2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Lgi2, LGI2 UniProt Number: Q8N0V4
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ABN335
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN335
      DescriptionAnti-LGI2 Antibody
      Alternate Names
      • Leucine-rich
      • glioma inactivated 2
      • LGIL2
      Background InformationLeucine-rich repeat LGI family member 2 (LGI2) is a member of the LGI family. The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the LGI2 protein using this Anti-LGI2 validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected LGI2 in human midbrain tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the N-terminus of human LGI2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins. Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • Lgi2
      • LGI2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~63 kDa observed. An uncharacterized band may appear at ~49 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected LGI2 in 15 µg/mL of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN335 04053252831157