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MABC40 Anti-LAMP-2 Antibody, clone ABL-93

Anti-LAMP-2 Antibody, clone ABL-93 is an antibody against LAMP-2 for use in WB, IP & IF.

Anti-LAMP-2 Antibody, clone ABL-93 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: CD107b, LAMPB, LGP110, LAMP-2 UniProt Number: P17047
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MABC40
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IP, IFRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC40
      DescriptionAnti-LAMP-2 Antibody, clone ABL-93
      Alternate Names
      • lysosomal-associated membrane protein 2
      • CD107 antigen-like family member B
      • CD107b antigen
      Background InformationLysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy.
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Control
      • NIH/3T3 cell lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LAMP-2 Antibody, clone ABL-93 is an antibody against LAMP-2 for use in WB, IP & IF.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunofluorescence
      Application NotesImmunoprecipitation Analysis: This antibody has been shown to immunoprecipitate LAMP-2 in HaNIH cells, (Chen, 1985).

      Immunofluorescence Analysis: This antibody has been shown to detect LAMP-2 in mouse brain, (Ferguson, 2009).
      Biological Information
      ImmunogenPurified glycoproteins from NIH/3T3 cells, corresponding to mouse LAMP-2.
      CloneABL-93
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityThis antibody recognizes LAMP-2.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD107b
      • LAMPB
      • LGP110
      • LAMP-2
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

      PTM: O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans (by similarity).

      SEQUENCE SIMILARITIES: Belongs to the LAMP family.
      Molecular Weight ~ 80 kDa observed MW. The calculated MW is 45 kDa. LAMP-2 is heavily glycosoated and has been routinely observed at MW's of 80-120 kDa based on publication data, (Chen, 1985; Ferguson, 2009).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-2 in 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC40 04053252523854

      Documentation

      Anti-LAMP-2 Antibody, clone ABL-93 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-LAMP-2 Antibody, clone ABL-93 Certificates of Analysis

      TitleLot Number
      Anti-LAMP-2, clone ABL-93 - 2445072 2445072
      Anti-LAMP-2, clone ABL-93 - 2012968 2012968
      Anti-LAMP-2, clone ABL-93 - 2197282 2197282
      Anti-LAMP-2, clone ABL-93 - 2330621 2330621
      Anti-LAMP-2, clone ABL-93 - 2512069 2512069
      Anti-LAMP-2, clone ABL-93 - 2986035 2986035
      Anti-LAMP-2, clone ABL-93 - 3443366 3443366
      Anti-LAMP-2, clone ABL-93 - 3490113 3490113
      Anti-LAMP-2, clone ABL-93 - 3819210 3819210
      Anti-LAMP-2, clone ABL-93 - 3931713 3931713
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