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AB1967 Anti-Integrin αIIb Antibody, cytoplasmic domain

Anti-Integrin αIIb Antibody, cytoplasmic domain is an antibody against Integrin αIIb for use in ELISA & IP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGA2B, CD41B, GPIIb, HPA3, GP2B, ITGAB, CD41, GTA UniProt Number: P08514
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AB1967
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, IPRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1967
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin αIIb Antibody, cytoplasmic domain
      Alternate Names
      • Glycoprotein IIb
      • CD41 Antigen
      Product Information
      FormatSerum
      PresentationWhole rabbit serum. Liquid containing no preservative.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin αIIb Antibody, cytoplasmic domain is an antibody against Integrin αIIb for use in ELISA & IP.
      Key Applications
      • ELISA
      • Immunoprecipitation
      Application NotesImmunoprecipitation

      ELISA: Direct 1:500 with 5% milk in PBS or TBS at pH 7.4

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the cytoplasmic domain of human integrin alphaIIb

      conjugated to KLH. (a.a. 1020-1039, KVGFFKRNRPPLEEDDEEGE)
      Epitopecytoplasmic domain
      HostRabbit
      SpecificityHuman integrin alpha Iib
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA2B
      • CD41B
      • GPIIb
      • HPA3
      • GP2B
      • ITGAB
      • CD41
      • GTA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08514 # Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
      SIZE: 1039 amino acids; 113391 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
      DISEASE: SwissProt: P08514 # Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
      SIMILARITY: SwissProt: P08514 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20ºC in undiluted aliquots for up to twelve months from date of receipt. Avoid

      repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      AB1967 04053252589829