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AB5401 Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 is an antibody against Growth Associated Protein 43 for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuroregenerative Medicine, Signaling Neuroscience Gene Symbol: GAP43, PP46, Neuromodulin, B-50, neuromodulin UniProt Number: P17677
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AB5401
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5401
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Growth Associated Protein 43 Antibody, phosphoSer 41
      Alternate Names
      • GAP-43
      • Neuromodulin
      Background InformationGAP-43, a common marker of differentiating neurons, is expressed at elevated levels by developing or regenerating neurons during axon growth. While GAP-43 is an integral membrane protein associated with the cytoplasmic surface of axonal growth cones (and synapses), it is absent from dendritic growth cones. In adult brain, GAP-43 is found in high concentration in presynaptic areas where memory formation is thought to occur, such as frontal cortex, limbic system and hippocampus. Phosphorylation of GAP-43 by PKC (at Ser41 on human, mouse, rat, and bovine GAP-43 or Ser42 on chicken and Xenopus GAP-43) is specifically correlated with certain forms of synaptic plasticity.
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin in 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 μg/mL BSA and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Growth Associated Protein 43 Antibody, phosphoSer 41 is an antibody against Growth Associated Protein 43 for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000 (43kDa band).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids surrounding the phosphoSer41 of rat GAP-43. This is the site phosphorylated by protein kinase C.
      EpitopephosphoSer 41
      HostRabbit
      SpecificityGAP-43 phosphoSer41. The labeling of the GAP-43 protein (~43kDa) in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. In some tissues the antibody may recognize a lower molecular weight band. This band is also detected by a pan GAP-43 antibody.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This encoded protein is considered a crucial component of an effective regenerative response in the nervous system.
      Gene Symbol
      • GAP43
      • PP46
      • Neuromodulin
      • B-50
      • neuromodulin
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17677 # This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons.
      SIZE: 238 amino acids; 24803 Da
      SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
      PTM: Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
      SIMILARITY: SwissProt: P17677 ## Belongs to the neuromodulin family. & Contains 1 IQ domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5401 04053252623776

      Documentation

      Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-GAP-43 phospoSer41 - 3587184 3587184
      RABBIT ANTI-GAP-43 phospoSer41 - 3601665 3601665
      RABBIT ANTI-GAP-43 phospoSer41 - 3883558 3883558
      RABBIT ANTI-GAP-43 phospoSer41 - 4012113 4012113
      RABBIT ANTI-GAP-43 phospoSer41 - 4138108 4138108
      RABBIT ANTI-GAP-43 phospoSer41 -2634224 2634224
      RABBIT ANTI-GAP-43 phospoSer41 -2641730 2641730
      RABBIT ANTI-GAP-43 phospoSer41 -2706702 2706702
      RABBIT ANTI-GAP-43 phospoSer41 -2717612 2717612
      RABBIT ANTI-GAP-43 phospoSer41 -2757857 2757857
      Show more

      References

      Reference overviewPub Med ID
      Axonal rearrangement without reexpression of a growth associated marker: evidence from the compression of the retinotectal system in adult goldfish.
      Keyuan Si,Jill A Miotke,Ronald L Meyer,Ziren Wang
      Restorative neurology and neuroscience  25  2007

      Show Abstract       		18334771 18334771

      Data Sheet

      Title
      RABBIT ANTI-GAP-43 phospoSer41 AFFINITY PURIFIED

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies