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AB15157 Anti-Ghrelin Antibody, active & proform

This Anti-Ghrelin Antibody, active & proform is validated for use in WB for the detection of Ghrelin.

Anti-Ghrelin Antibody, active & proform MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: CNS Control of Metabolism Gene Symbol: GHRL, ghrelin, obestatin, MTLRP UniProt Number: Q9UBU3
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AB15157
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB15157
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Ghrelin Antibody, active & proform
      Product Information
      FormatSerum
      PresentationLiquid.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Ghrelin Antibody, active & proform is validated for use in WB for the detection of Ghrelin.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:5,000-1:10,000 on extracts from mouse stomach.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      HostRabbit
      SpecificityGhrelin, active & proform. By Western blot the antibody recognizes a band at ~13 kDa using mouse stomach lysate. The band is completed abolished after incubating the antibody with the immunogen peptide.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGhrelin is an endogenous ligand for the growth hormone secretagogue receptor (GHSR; MIM 601898) and is involved in regulating growth hormone (GH; MIM 139250) release. Ghrelin is derived from a preprohormone called preproghrelin, which also generates a second peptide called obestatin. Obestatin is an endogenous ligand for the orphan G protein-coupled receptor GPR39 (MIM 602886) and is involved in satiety and decreased food intake.[supplied by OMIM]
      Gene Symbol
      • GHRL
      • ghrelin
      • obestatin
      • MTLRP
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
      SIZE: 117 amino acids; 12911 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
      PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
      SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      AB15157 04053252338922