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AB5459 Anti-GABA A Receptor α4 Antibody, CT

Anti-GABA A Receptor α4 Antibody, C-terminus is an antibody against GABA A Receptor α4 for use in IP & WB.

Anti-GABA A Receptor α4 Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GABRA4, GABA UniProt Number: P48169
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AB5459
100 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5459
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-GABA A Receptor α4 Antibody, CT
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationAnti-GABA A Receptor α4 Antibody, C-terminus is an antibody against GABA A Receptor α4 for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1:1,000

      Immunopreciptation: The antibody will immunoprecipitate 8% of all GABA A receptors in sodium dodecyl sulfate extracts of rat forebrains (150 μL) using 20 μg of antibody.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMBP fusion protein from the cytosolic loop of rat GABA A receptor alpha4 subunit.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityGABA A receptor alpha4 subunit. The apparent molecular mass of the alpha 4 subunit in rat brain membrane fractions is 64 kDa.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
      Gene Symbol
      • GABRA4
      • GABA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48169 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
      SIZE: 554 amino acids; 61640 Da
      SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
      SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: P48169 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5459 04053252408083

      Documentation

      Anti-GABA A Receptor α4 Antibody, CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GABA A Receptor α4 Antibody, CT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2449220 2449220
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 - 3190908 3190908
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 - 3856684 3856684
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 - 4016253 4016253
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 - 4030500 4030500
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 - 4146073 4146073
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 -2798364 2798364
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 AFFINITY PURIFIED POLYCLONAL ANTIBODY 2925263
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3088415
      RABBIT ANTI-GABAA RECEPTOR ALPHA4 AFFINITY PURIFIED POLYCLONAL ANTIBODY 2986579

      References

      Reference overviewPub Med ID
      mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism.
      Fatemi, SH; Reutiman, TJ; Folsom, TD; Rooney, RJ; Patel, DH; Thuras, PD
      Journal of autism and developmental disorders  40  743-50  2010

      Show Abstract       		20066485 20066485