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ABD137 Anti-ESRRB Antibody

Anti-ESRRB Antibody detects level of ESRRB & has been published & validated for use in ESRRB.

Anti-ESRRB Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Pluripotent & Early Differentiation Gene Symbol: ESRRB, ERRB2, ESRL2, NR3B2 UniProt Number: O95718
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ABD137
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABD137
      DescriptionAnti-ESRRB Antibody
      Alternate Names
      • Steroid hormone receptor ERR2
      • ERR beta-2
      • Estrogen receptor-like 2
      • Estrogen-related receptor beta
      • ERR-beta
      • Nuclear receptor subfamily 3 group B member 2
      Background InformationSteroid hormone receptor ERR2, also known as ERR beta-2 or Estrogen receptor-like 2 or Estrogen-related receptor beta (ERR-beta), and encoded by the gene name ESRRB or ERRB2 or ESRL2, was initially identified in mouse embryonic carcinoma stem cells and was found to be expressed exclusively in trophoblast progenitor cells between days 6.5 and 7.5 post coitum. Recent studies have shown that ESRRB is part of an POU5F1/Oct4-centered protein interaction network in embryonic stem (ES) cells. It is thought to interact with other ES transcription factors such as NANOG within this network, activating POU5F1 transcription and thereby sustaining self-renewal and pluripotency in ES cells. Mutations in ESRRB have been associated with autosomal recessive deafness which is a form of non-syndromic deafness characterized by non-progressive, prelingual hearing loss.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ESRRB Antibody detects level of ESRRB & has been published & validated for use in ESRRB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the N-terminus of human ESRRB.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityUniprot describes 2 isoforms produced by alternative splicing at ~56 kDa and 1 isoform at ~48 kDa.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • ESRRB
      • ERRB2
      • ESRL2
      • NR3B2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~59 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Human heart tissue lysate with and without blocking peptide.

      Western Blotting Analysis: 1 μg/mL of this antibody detected ESRRB in Human heart tissue lysate with and without blocking peptide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABD137 04053252945250

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies