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MABT1526-25UG Anti-Cadherin 17 Antibody, clone 7C5

Anti-Cadherin 17, clone 7C5, Cat. No. MABT1526, is a mouse monoclonal antibody that detects Cadherin 17 and has been tested for use in Immunohistochemistry (Paraffin).

MABT1526-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABT1526-25UG
      DescriptionAnti-Cadherin 17 Antibody, clone 7C5
      Alternate Names
      • Intestinal peptide-associated transporter HPT-1
      • Liver-intestine cadherin
      • LI-cadherin
      Background InformationCadherin 17 (UniProt: Q12864; also known as Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin) is encoded by the CDH17 gene (Gene ID: 1015) in human. Cadherins are calcium-dependent cell adhesion molecules that participate in cell-cell adhesion during embryogenesis, development, organogenesis, and differentiation. Cadherin 17 is a single-pass type I membrane glycoprotein. It is predominantly expressed in the gastrointestinal tract and pancreatic duct and is not detected in kidney, lung, liver, brain, adrenal gland, and skin. It is synthesized with a signal peptide (aa 1-22), which is cleaved off to generate the mature form that contains an extracellular domain (aa 23-787), transmembrane domain (aa 788-808), and a cytoplasmic domain (aa 809-832). It differs from classical cadherins in having a short cytoplasmic tail at its carboxyl-terminus. In the extracellular region it has 7 cadherin domains. Three calcium ions are usually bound at the interface of each cadherin domain that rigidify the connections, imparting a strong curvature to the full-length ectodomain. Cadherin-17 expression has been described in several gastric carcinomas and it is shown to be a good immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. It is considered as an oncofetal molecule associated with poor prognostic outcomes of hepatocellular carcinoma. (Ref.: Wang, Y., et al. (2013). PLoS One. 8(9); e72386).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Cadherin 17, clone 7C5, Cat. No. MABT1526, is a mouse monoclonal antibody that detects Cadherin 17 and has been tested for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenRecombinant human Cadherin 17-Fc Protein.
      Epitopeextracellular domain
      Clone7C5
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 7C5 is a a mouse monoclonal antibody that detects human Cadherin 17.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CDH17
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight92.22 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human small intestine tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected Cadherin 17 in human small intestine tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT1526-25UG 04061841235958