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MABF1488 Anti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody

This mouse monoclonal Anti- CD161 (NK1.1) Antibody (mouse), APC, clone PK136, Cat. No. MABF1488 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Klrb1b, Ly55b, Nkrp1b UniProt Number: P27812
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MABF1488
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCMAPCMonoclonal Antibody
      Description
      Catalogue NumberMABF1488
      DescriptionAnti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody
      Alternate Names
      • Killer cell lectin-like receptor subfamily B member 1B allele A
      • CD161 antigen-like family member B
      • Lymphocyte antigen 55b (Ly-55b)
      • NKR-P1 34
      • Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B)
      • CD161b
      • CD161 (NK1.1)
      Background InformationThe PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
      Product Information
      FormatAPC
      PresentationPurified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti- CD161 (NK1.1) Antibody (mouse), APC, clone PK136, Cat. No. MABF1488 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      ClonePK136
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Klrb1b
      • Ly55b
      • Nkrp1b
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD161 (NK1.1) in one million C57Bl/6 splenocytes stained with FITC Anti-mouse CD3e.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 μg
      Global Trade Item Number
      Catalogue Number GTIN
      MABF1488 04055977293326