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ABC97 Anti-Birc7/LIVIN Antibody

Anti-Birc7/LIVIN detects levels of Birc7/LIVIN proteins & has been published & validated for use in WB.

Anti-Birc7/LIVIN Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BIRC7, KIAP, LIVIN, MLIAP, RNF50 UniProt Number: Q96CA5
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ABC97
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC97
      DescriptionAnti-Birc7/LIVIN Antibody
      Alternate Names
      • Baculoviral IAP repeat-containing protein 7
      • Kidney inhibitor of apoptosis protein
      • KIAP
      • Livin
      • Melanoma inhibitor of apoptosis protein
      • ML-IAP
      • RING finger protein 50
      Background InformationLivin, also known as “baculoviral IAP repeat-containing protein 7” (Birc7) and "KIAP," is a member of the IAP (inhibitors of apoptosis) family of proteins characterized by highly conserved baculoviral IAP repeats (BIR). In addition, Livin contains one RING-type zinc finger domain. Livin has been detected in the heart, placental, lung, lymph node, ovary, spleen, and in various types of solid tumors. It may suppress apoptosis induced by TNF, viral infection, drugs, and growth factor withdrawal, by inhibiting caspase activity (caspase 3, 7, and 9) and activating a MAPK/JUN pathway. Paradoxically, Livin may also function as a pro-apoptic factor in a truncated form (tLivin) that is cleaved by caspase 3 from the full-length protein. The pro-apoptotic effects of Livin may depend on its RING domain. Livin may play a role in non-Hodgkin lymphoma.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human spleen tissue lysate
      PresentationPurified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Birc7/LIVIN detects levels of Birc7/LIVIN proteins & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the BIR repeat region of human Birc7/LIVIN.
      EpitopeBIR repeat region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the BIR repeat region of Birc7/LIVIN.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Rat, Mouse, and Bovine (93% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BIRC7
      • KIAP
      • LIVIN
      • MLIAP
      • RNF50
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~39 kDa, ~32 kDa observed. Two isoforms at 32 kDa and 30 kDa are known to exist. This protein has been observed at ~39 kDa (alpha) and ~37 kDa (beta) due to post translational modification (Nachmias, B., et al. (2007). Apoptosis. 12(7):1129-1142.).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human spleen tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Birc7/LIVIN in 10 µg of human spleen tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC97 04053252441493

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies