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AB2232 Anti-Atrial Natriuretic Polypetide Antibody, alpha

This Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: ANF , ANP, CDD-ANF, OTTHUMP00000002504, OTTHUMP00000044485, PND , Prepronatriodilatin, pronatriodilatin UniProt Number: P01160
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AB2232
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2232
      DescriptionAnti-Atrial Natriuretic Polypetide Antibody, alpha
      Alternate Names
      • Atrial natriuretic peptide
      • natriuretic peptide precursor A
      • natriuretic peptide precursor A variant 2
      Background InformationAtrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1).
      Product Information
      FormatPurified
      Control
      • Rat Heart
      PresentationPurified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.
      Key Applications
      • Western Blotting
      Application NotesNon-Lot Specific Tested Application 1:
      Immunohistochemistry:
      1:50-1:500 on paraffin embedded tissue.

      Optimum dilutions need to be determined by the end user.
      Biological Information
      ImmunogenSynthetic Linear Peptide
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB2232 recognizes ANP, alpha
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteRat, Human and Mouse. May react with dog, cat and cow based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANF
      • ANP
      • CDD-ANF
      • OTTHUMP00000002504
      • OTTHUMP00000044485
      • PND
      • Prepronatriodilatin
      • pronatriodilatin
      Purification MethodPurified
      UniProt Number
      UniProt SummaryFUNCTION: A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity.
      SUBUNIT: Interacts with NPR3.
      LOCATION: Secreted.
      POLYMORPHISM: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.
      SIMILARITY: Belongs to the natriuretic peptide family.
      Molecular Weight~17 kDa
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      AB2232 04053252621215