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AB10323 Anti-3A7 Antibody

This Anti-3A7 Antibody is validated for use in WB for the detection of 3A7.

Anti-3A7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: CP37, CYPIIIA7, EC 1.14.14.1 , P450-HFLA UniProt Number: P24462
AB10323
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10323
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-3A7 Antibody
      Alternate Names
      • Cytochrome P450 3A7
      Background InformationHuman cytochrome P450 3A7 (CYP3A7) is expressed from early in gestation until the perinatal period, when there is a switch in expression to CYP3A4. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
      References
      Product Information
      FormatSerum
      PresentationRaw rabbit serum with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-3A7 Antibody is validated for use in WB for the detection of 3A7.
      Key Applications
      • Western Blotting
      Application NotesSuggested dilutions:
      Western Blot: 1:5000
      Biological Information
      ImmunogenRecombinant human 3A7
      EpitopeAA 214 to 263
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
      Gene Symbol
      • CP37
      • CYPIIIA7
      • EC 1.14.14.1
      • P450-HFLA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P24462# Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
      SIZE: 503 amino acids; 57526 Da
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
      SIMILARITY: SwissProt: P24462# Belongs to the cytochrome P450 family.
      Molecular Weight61 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10323 04053252508493