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164599 Aminopeptidase N, Rat

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164599
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164599-10U
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      Description
      OverviewNative aminopeptidase N purified from rat renal brush-border membranes and cleaved with papain to produce soluble enzyme. A single-chain, integral membrane protease that, functions with broad specificity to remove N-terminal amino acids from peptides. It has been reported that levels of aminopeptidase N are elevated in cancer subjects and correlate with tumor load, and thus, the enzyme is believed to play a role in angiogenesis.
      Catalogue Number164599
      Brand Family Calbiochem®
      SynonymsAPN/CD13, aminopeptidase N
      References
      ReferencesBhagwat, S.V., et al. 2003. Blood 101, 1818.
      van Hensbergen, Y., et al. 2002. Clin. Cancer Res. 8, 3747.
      Ishii, K., et al. 2001. Biol. Pharm. Bull. 24, 226.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol L-Leu-<i>p</i>NA per min at 37°C, pH 7.2
      EC number3.4.11.2
      FormLiquid
      FormulationIn 200 mM NaCl, 50 mM Tris-HCl, pH 8.0.
      Quality LevelMQ100
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥100 units/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
      Global Trade Item Number
      Catalogue Number GTIN
      164599-10U 04055977207583