Millipore Sigma Vibrant Logo

182690 AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem

The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine

View Products on Sigmaaldrich.com
182690
View Pricing & Availability

Overview

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
182690-10MG
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
      Catalogue Number182690
      Brand Family Calbiochem®
      Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
      References
      ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
      Product Information
      CAS number574759-62-9
      FormWhite solid
      Hill FormulaC₁₇H₁₁ClF₃N₃
      Chemical formulaC₁₇H₁₁ClF₃N₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      182690-10MG 04055977204445