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119140 Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem

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119140-10MG
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      Description
      OverviewA cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM, 2.4 µM and 6.2 nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1 µM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
      Catalogue Number119140
      Brand Family Calbiochem®
      Synonyms(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide
      References
      ReferencesForster, K., et al. 2006. Basic Res. Cardiol. 101, 319.
      de Zwart, M., et al. 1998. Nucleosides Nucleotides. 17, 969.
      Phillis, J. et al. 1986, Pharm. Biochem. Behavior.24, 263
      Durcan, M. J., et al. 1989. Pharmacol Biochem Behav. 32, 487.
      Bacher, S., et al. 1982. Naunyn Schmiedebergs Arch Pharmacol. 329, 67.
      Cusack, N., et al. 1981. Br J Pharm.72, 443.
      Londos, C., et al. 1980. Proc Natl Acad Sci.77, 2551.
      Product Information
      CAS number35920-39-9
      FormWhite solid
      Hill FormulaC₁₂H₁₆N₆O₄
      Chemical formulaC₁₂H₁₆N₆O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target K<sub>i</sub>14 nM
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      119140-10MG 04055977223354