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118415 ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

ADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄

Primary Target: PARG
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118415
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O

Pricing & Availability

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118415-1SET
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      118415-60UG
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          Description
          OverviewAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
          Note: 1 set = 5 x 60 µg
          Catalogue Number118415
          Brand Family Calbiochem®
          SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
          References
          ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
          Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
          Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
          Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).
          Biological Information
          Primary TargetPARG
          Primary Target IC<sub>50</sub>120 nM against poly(ADP-ribose) glycohydrolase (PARG)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          118415-1SET 04055977224009
          118415-60UG 07790788047887

          Documentation

          ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem Certificates of Analysis

          TitleLot Number
          118415

          References

          Reference overview
          Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
          Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
          Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.

          Technical Info

          Title
          Data Sheet - 118415 Envirocheck Contact plates VRB agar (Violet Red Bile Agar)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
          DescriptionAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50 = 120 nM) vs. ADP-ribose (IC50 = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.
          FormWhite lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage Protect from light
          -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
          Toxicity Standard Handling
          ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
          Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
          Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.