100068 Sigma-Aldrich17-AAG - CAS 75747-14-7 - Calbiochem
A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.
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Synonyms: NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 75747-14-7 | C₃₁H₄₃N₃O₈ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 100068-500UG |
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Plastic ampoule | 500 μg |
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| Description | |
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| Overview | A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression. |
| Catalogue Number | 100068 |
| Brand Family | Calbiochem® |
| Synonyms | NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin |
| Product Information | |
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| CAS number | 75747-14-7 |
| ATP Competitive | N |
| Form | Purple solid |
| Hill Formula | C₃₁H₄₃N₃O₈ |
| Chemical formula | C₃₁H₄₃N₃O₈ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Hsp90 |
| Primary Target IC<sub>50</sub> | EC50 = 7.2 µM for Hsp90 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 100068-500UG | 04055977226881 |
Documentation
17-AAG - CAS 75747-14-7 - Calbiochem SDS
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17-AAG - CAS 75747-14-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 100068 |
References
| Reference overview |
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| Basso, A.D., et al. 2002. Oncogene 21, 1159. Clarke, P.A., et al. 2002. Oncogene 19, 4125. Clarke, P.A., et al. 2000. Oncogene 19, 4125. Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273. Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806. |
Data Sheet
| Title |
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| Data Sheet 1.00068.0500 |
User Guides
| Title |
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| Pack insert Bolton Broth Selective Supplement 1.00079.0010 |
| Packungsbeilage Bolton Bouillon Selektiv-Supplement 1.00079.0010 |