344036 Sigma-AldrichcFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
The cFMS Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 870483-87-7, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The cFMS Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 870483-87-7, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 870483-87-7 | C₂₀H₂₂N₄O₃ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 344036-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
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| Overview | A cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available. |
| Catalogue Number | 344036 |
| Brand Family | Calbiochem® |
| Synonyms | 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580 |
| References | |
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| References | Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078. |
| Product Information | |
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| CAS number | 870483-87-7 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₂₀H₂₂N₄O₃ |
| Chemical formula | C₂₀H₂₂N₄O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | CFMS |
| Primary Target IC<sub>50</sub> | 30 nM against cFMS kinase activity |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 344036-1MG | 04055977195149 |
Documentation
cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem SDB
| Titel |
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cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 344036 |
Literatur
| Übersicht |
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| Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078. |