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382425 Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.

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Synonyme: 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725

Primary Target: cGMP-inhibited phosphodiesterase
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382425
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
78416-81-6C₂₄H₂₇N₃O₃ · HCl

Preis & Verfügbarkeit

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382425-10MG
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      		 Kst.-Ampulle 10 mg
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      Description
      OverviewExtremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
      Catalogue Number382425
      Brand Family Calbiochem®
      Synonyms9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
      References
      ReferencesSpina, D., et al. 1998. Life Sci. 62, 953.
      Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
      Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
      Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
      Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
      DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
      Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
      Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.
      Product Information
      CAS number78416-81-6
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₄H₂₇N₃O₃ · HCl
      Chemical formulaC₂₄H₂₇N₃O₃ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetcGMP-inhibited phosphodiesterase
      Primary Target IC<sub>50</sub>300 pM against cGMP-inhibited phosphodiesterase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUW7727000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      382425-10MG 04055977190250

      Documentation

      Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      382425

      Literatur

      Übersicht
      Spina, D., et al. 1998. Life Sci. 62, 953.
      Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
      Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
      Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
      Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
      DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
      Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
      Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-July-2008 RFH
      Synonyms9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
      DescriptionExtremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
      FormPale yellow solid
      CAS number78416-81-6
      RTECSUW7727000
      Chemical formulaC₂₄H₂₇N₃O₃ · HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (500 µM)
      Storage Protect from moisture
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSpina, D., et al. 1998. Life Sci. 62, 953.
      Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
      Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
      Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
      Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
      DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
      Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
      Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.