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581011 Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem

The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: MST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine

Primary Target: TRAP lysate prepared from U937 cells
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581011
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
368449-04-1C₂₀H₁₆N₂O₆

Preis & Verfügbarkeit

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581011-10MG
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      Description
      OverviewA cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).
      Catalogue Number581011
      Brand Family Calbiochem®
      SynonymsMST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine
      References
      ReferencesSeimiya, H., et al. 2005. Cancer Cell 7, 25.
      Seimiya, H., et al. 2002. Mol. Cancer Ther. 1, 657.
      Product Information
      CAS number368449-04-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₁₆N₂O₆
      Chemical formulaC₂₀H₁₆N₂O₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTRAP lysate prepared from U937 cells
      Primary Target IC<sub>50</sub>670 nM against telomerase activity in TRAP lysate prepared from U937 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      581011-10MG 04055977265613

      Documentation

      Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      581011

      Literatur

      Übersicht
      Seimiya, H., et al. 2005. Cancer Cell 7, 25.
      Seimiya, H., et al. 2002. Mol. Cancer Ther. 1, 657.

      Broschüre

      Titel
      Caspases and other Apoptosis Related Tools Brochure