616521 Sigma-AldrichTRPV4 Antagonist II, HC-067047 - CAS 883031-03-6 - Calbiochem
The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.
More>> The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 883031-03-6 | C₂₆H₂₈F₃N₃O₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 616521-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780 nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo. |
| Catalogue Number | 616521 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047 |
| References | |
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| References | Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 19084. |
| Product Information | |
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| CAS number | 883031-03-6 |
| Form | White solid |
| Hill Formula | C₂₆H₂₈F₃N₃O₂ |
| Chemical formula | C₂₆H₂₈F₃N₃O₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 616521-10MG | 04055977185256 |
Documentation
TRPV4 Antagonist II, HC-067047 - CAS 883031-03-6 - Calbiochem SDB
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TRPV4 Antagonist II, HC-067047 - CAS 883031-03-6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 616521 |
Literatur
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| Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 19084. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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