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654257 TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem

The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.

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Synonyme: 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline

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654257
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
303997-35-5C₁₆H₈ClF₃N₄S

Preis & Verfügbarkeit

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654257-10MG
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      Description
      OverviewA cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
      Catalogue Number654257
      Brand Family Calbiochem®
      Synonyms8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
      References
      ReferencesGururaja, T.L., et al. 2007. Chem. Biol. 14, 1105.
      Product Information
      CAS number303997-35-5
      FormLight yellow powder
      Hill FormulaC₁₆H₈ClF₃N₄S
      Chemical formulaC₁₆H₈ClF₃N₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      654257-10MG 04055977184648

      Documentation

      TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      654257

      Literatur

      Übersicht
      Gururaja, T.L., et al. 2007. Chem. Biol. 14, 1105.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
      DescriptionA cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
      FormLight yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number303997-35-5
      Chemical formulaC₁₆H₈ClF₃N₄S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGururaja, T.L., et al. 2007. Chem. Biol. 14, 1105.