616452 MilliporeTGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation)
More>> TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
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Übersicht
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 446859-33-2 | C₁₇H₁₃N₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 616452-2MG |
|
Glasflasche | 2 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158). |
| Catalogue Number | 616452 |
| Brand Family | Calbiochem® |
| Synonyms | ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
| References | |
|---|---|
| References | Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494. Ichida, J. K., et al. 2009. 5, 491. |
| Product Information | |
|---|---|
| CAS number | 446859-33-2 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₇H₁₃N₅ |
| Chemical formula | C₁₇H₁₃N₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | ALKS binding |
| Primary Target IC<sub>50</sub> | 23 nM |
| Secondary target | ALK 5 auto phosphorylation (IC₅₀ = 4 nM) |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 616452-2MG | 04055977185829 |