579051 Sigma-AldrichTAPI-1 - CAS 171235-71-5 - Calbiochem
TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.
More>> TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins. Less<<TAPI-1 - CAS 171235-71-5 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
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| 171235-71-5 | C₂₆H₃₇N₅O₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 579051-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
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| Overview | A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α converting enzyme/ADAM17). TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive (IC50 = 8.09 µM) and muscarinic receptor-stimulated (IC50 = 3.61 µM) sAAPα release in HEK 293 cells expressing M3 muscarinic receptors. A 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579050) in DMSO is also available. |
| Catalogue Number | 579051 |
| Brand Family | Calbiochem® |
| Synonyms | N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1 |
| Product Information | |
|---|---|
| CAS number | 171235-71-5 |
| ATP Competitive | N |
| Declaration | Manufactured exclusively by Peptides International, Louisville, Kentucky, USA. |
| Form | White solid |
| Hill Formula | C₂₆H₃₇N₅O₅ |
| Chemical formula | C₂₆H₃₇N₅O₅ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | N |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 579051-1MG | 04055977265361 |
Documentation
TAPI-1 - CAS 171235-71-5 - Calbiochem SDB
| Titel |
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TAPI-1 - CAS 171235-71-5 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 579051 |
Literatur
| Übersicht |
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| Slack, B.E., et al. 2001. Biochem. J. 357, 787. Vincent, B., et al. 2001. J. Biol. Chem. 276, 37743. Hooper, N.M., et al. 1997. Biochem. J. 321, 265. Crowe, P.D., et al. 1995. J. Exp. Med. 181, 1205. Mullberg, J., et al. 1995. J. Immunol. 155, 5198. Mohler, K.M., et al. 1994. Nature 370, 218. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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