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505484 SB-277011-A Dihydrochloride - CAS 1226917-67-4 - Calbiochem

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A

Primary Target: D3
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505484
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1226917-67-4C₂₈H₃₀N₄O•2HCl

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      Description
      OverviewA brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
      Catalogue Number505484
      Brand Family Calbiochem®
      SynonymsSB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
      References
      ReferencesCollins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
      Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.
      Product Information
      CAS number1226917-67-4
      FormWhite solid
      Hill FormulaC₂₈H₃₀N₄O•2HCl
      Chemical formulaC₂₈H₃₀N₄O•2HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD3
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5054840001 04055977243369

      Documentation

      SB-277011-A Dihydrochloride - CAS 1226917-67-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
      Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2013 JSW
      SynonymsSB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
      DescriptionA brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
      FormWhite solid
      CAS number1226917-67-4
      Chemical formulaC₂₈H₃₀N₄O•2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCollins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
      Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.