559389 Sigma-AldrichSB 203580 - CAS 152121-47-6 - Calbiochem
SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
More>> SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells). Less<<SB 203580 - CAS 152121-47-6 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI
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Übersicht
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 152121-47-6 | C₂₁H₁₆N₃OSF |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 559389-10MG |
|
Glasflasche | 10 mg |
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| 559389-1MG |
|
Kst.-Ampulle | 1 mg |
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| 559389-5MG |
|
Glasflasche | 5 mg |
|
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| Description | |
|---|---|
| Overview | Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available. |
| Catalogue Number | 559389 |
| Brand Family | Calbiochem® |
| Synonyms | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI |
| Product Information | |
|---|---|
| CAS number | 152121-47-6 |
| ATP Competitive | Y |
| Form | Thin film |
| Hill Formula | C₂₁H₁₆N₃OSF |
| Chemical formula | C₂₁H₁₆N₃OSF |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 559389-10MG | 04055977192490 |
| 559389-1MG | 07790788051532 |
| 559389-5MG | 04055977192537 |