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540500 Purvalanol A - CAS 212844-53-6 - Calbiochem

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

Purvalanol A - CAS 212844-53-6 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine

Primary Target: Cdc2/cyclin B
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540500
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
212844-53-6C₁₉H₂₅ClN₆O

Preis & Verfügbarkeit

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      Description
      OverviewA potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2/cyclin B; IC50 = 70 nM for Cdk2/cyclin A; IC50 = 35 nM for Cdk2/cyclin E; and IC50 = 75 nM for Cdk5/p35).
      Catalogue Number540500
      Brand Family Calbiochem®
      Synonyms2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
      References
      ReferencesGray, N.S., et al. 1998. Science 281, 533.
      Product Information
      CAS number212844-53-6
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
      FormOff-white solid
      Hill FormulaC₁₉H₂₅ClN₆O
      Chemical formulaC₁₉H₂₅ClN₆O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdc2/cyclin B
      Primary Target IC<sub>50</sub>4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      540500-1MG 04055977268812

      Documentation

      Purvalanol A - CAS 212844-53-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Purvalanol A - CAS 212844-53-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      540500

      Literatur

      Übersicht
      Gray, N.S., et al. 1998. Science 281, 533.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-December-2009 RFH
      Synonyms2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
      DescriptionA potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2-cyclin B; IC50 = 70 nM for Cdk2-cyclin A; IC50 = 35 nM for Cdk2-cyclin E; and IC50 = 75 nM for Cdk5-p35).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number212844-53-6
      Chemical formulaC₁₉H₂₅ClN₆O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesGray, N.S., et al. 1998. Science 281, 533.