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370653 PknG Inhibitor - CAS 329221-38-7 - Calbiochem

The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: Mycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017

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370653
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
329221-38-7C₁₃H₁₆N₂O₂S

Preis & Verfügbarkeit

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370653-10MG
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      Description
      OverviewA cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
      Catalogue Number370653
      Brand Family Calbiochem®
      SynonymsMycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
      References
      ReferencesScherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
      Walburger, A., et al. 2004. Science 304, 1800.
      Product Information
      CAS number329221-38-7
      FormLight brown solid
      Hill FormulaC₁₃H₁₆N₂O₂S
      Chemical formulaC₁₃H₁₆N₂O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      370653-10MG 04055977191639

      Documentation

      PknG Inhibitor - CAS 329221-38-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      PknG Inhibitor - CAS 329221-38-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      370653

      Literatur

      Übersicht
      Scherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
      Walburger, A., et al. 2004. Science 304, 1800.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsMycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
      DescriptionA cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
      FormLight brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number329221-38-7
      Chemical formulaC₁₃H₁₆N₂O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesScherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
      Walburger, A., et al. 2004. Science 304, 1800.