524400 Sigma-AldrichPhorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem
Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
More>> Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: PMA, TPA, PKC Activator I
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 16561-29-8 | C₃₆H₅₆O₈ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 524400-10MG |
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Glasflasche | 10 mg |
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| 524400-1MG |
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Glasflasche | 1 mg |
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| 524400-25MG |
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Glasflasche | 25 mg |
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| 524400-5MG |
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Glasflasche | 5 mg |
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| Description | |
|---|---|
| Overview | Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582). |
| Catalogue Number | 524400 |
| Brand Family | Calbiochem® |
| Synonyms | PMA, TPA, PKC Activator I |
| Product Information | |
|---|---|
| CAS number | 16561-29-8 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₃₆H₅₆O₈ |
| Chemical formula | C₃₆H₅₆O₈ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations. |
| Biological Information | |
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| Primary Target | Protein Kinase C |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | QH4377000 |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 524400-10MG | 04055977270952 |
| 524400-1MG | 04055977270945 |
| 524400-25MG | 04055977270969 |
| 524400-5MG | 04055977270976 |
Documentation
Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem SDB
| Titel |
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Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 524400 |
Literatur
| Übersicht |
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| Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263. |
Broschüre
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| Caspases and other Apoptosis Related Tools Brochure |
Literaturstellen
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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