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516568 PPARβ/δ Inverse Agonist - Calbiochem

Übersicht

Key Spec Table

Empirical Formula
C₁₉H₂₆N₂O₅S₂

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
516568-10MG
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      Glasflasche 10 mg
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      Description
      OverviewA cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR β/δ receptor (IC50 = 93 nM). Enhances the interaction of the PPARβ/δ ligand-binding domain with the co-repressor, SMRT-ID2 (EC50 = 10 nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARβ/δ- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages.
      Catalogue Number516568
      Brand Family Calbiochem®
      Synonymsmethyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate (ST247)
      References
      ReferencesNaruhn, S., et al. 2011., Mol Pharmacol. 80, 828.
      Product Information
      FormYellow solid
      Hill FormulaC₁₉H₂₆N₂O₅S₂
      Chemical formulaC₁₉H₂₆N₂O₅S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      516568-10MG 04055977198218