529573 Sigma-AldrichPP2 - CAS 172889-27-9 - Calbiochem
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).
More>> PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). Less<<PP2 - CAS 172889-27-9 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 172889-27-9 | C₁₅H₁₆ClN₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 529573-1MG |
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Kst.-Ampulle | 1 mg |
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| 529573-5MG |
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Glasflasche | 5 mg |
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| Description | |
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| Overview | A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available. |
| Catalogue Number | 529573 |
| Brand Family | Calbiochem® |
| Synonyms | AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine |
| References | |
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| References | Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
|---|---|
| CAS number | 172889-27-9 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₅H₁₆ClN₅ |
| Chemical formula | C₁₅H₁₆ClN₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | N |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 529573-1MG | 07790788051198 |
| 529573-5MG | 04055977269802 |
Documentation
PP2 - CAS 172889-27-9 - Calbiochem SDB
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PP2 - CAS 172889-27-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 529573 |
Literatur
| Übersicht |
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| Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
Broschüre
| Titel |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
| Bulk Product Guide |
Technische Informationen
| Titel |
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| Fluorescent Gelatin Degradation Assays for Investigating Invadopodia Formation |
Datenblatt
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Posters
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| Human Kinome & InhibitorSelect™ Libraries |
Literaturstellen
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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