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528100 PI-103 - CAS 371935-74-9 - Calbiochem

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
371935-74-9C₁₉H₁₆N₄O₃

Preis & Verfügbarkeit

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528100-1MG
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      Kst.-Ampulle 1 mg
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      528100-5MG
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      Eingeschränkte Verfügbarkeit
Eingeschränkte Verfügbarkeit
      Lieferbar 
      Produkt wurde eingestellt
      Begrenzter Lagerbestand
      Bestätigung der Verfügbarkeit erforderlich
        Restmenge: Angebot folgt
          Restmenge: Angebot folgt
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          Kontakt zum Kundenservice
          Contact Customer Service

          Kst.-Ampulle 5 mg
          Preis wird abgerufen...
          Preis nicht abrufbar
          Die Mindestmenge muss ein Vielfaches sein von
          Maximum Quantity is
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          Description
          OverviewA cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528101) in DMSO is also available.
          Catalogue Number528100
          Brand Family Calbiochem®
          Synonyms3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V
          References
          ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
          Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
          Knight, Z.A., et al. 2006. Cell 125, 733.
          Product Information
          CAS number371935-74-9
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₉H₁₆N₄O₃
          Chemical formulaC₁₉H₁₆N₄O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetDNA-PK, PI3-K, and mTOR
          Primary Target IC<sub>50</sub>2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110delta;, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Bestellnummer GTIN
          528100-1MG 04055977270457
          528100-5MG 04055977270464

          Documentation

          PI-103 - CAS 371935-74-9 - Calbiochem SDB

          Titel

          Sicherheitsdatenblatt (SDB) 

          PI-103 - CAS 371935-74-9 - Calbiochem Analysenzertifikate

          TitelChargennummer
          528100

          Literatur

          Übersicht
          Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
          Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
          Knight, Z.A., et al. 2006. Cell 125, 733.

          Posters

          Titel
          Human Kinome & InhibitorSelect™ Libraries
          Datenblatt

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-October-2010 RFH
          Synonyms3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V
          DescriptionA cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number371935-74-9
          Chemical formulaC₁₉H₁₆N₄O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml). Slight warming may be required for complete solubilization.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
          Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
          Knight, Z.A., et al. 2006. Cell 125, 733.