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MAC132 Mouse Anti-Human IgA, Secretory Antibody, Clone 4G10.1

This Mouse Anti-Human IgA, Secretory Antibody, Clone 4G10.1 is validated for use in Enzyme Immunoassay (ELISA) for the detection of Mouse Human IgA, Secretory.

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Research Category: Secondary & Control Antibodies Research Sub-Category: Secondary Antibodies Adsorbed for Dual Labeling
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MAC132
400 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAC132
      Replaces411423-400UG
      DescriptionMouse Anti-Human IgA, Secretory Antibody, Clone 4G10.1
      Background InformationThe Mouse Anti-Human IgA antibody is an IgG monomeric immunoglobulin, built of two heavy chains and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). It is affinity-purified and demonstrated to react with Human IgA with minimal or no cross-reaction to Human IgG or Human IgM. The target of this antibody, Human IgA, constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B-cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Mouse Anti-Human IgA, Secretory Antibody, Clone 4G10.1 is validated for use in Enzyme Immunoassay (ELISA) for the detection of Mouse Human IgA, Secretory.
      Key Applications
      • Enzyme Immunoassay (ELISA)
      Application NotesELISA. Can be used as a capture antibody for ELISA at 10 μg/ml in PBS without carrier protein. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      ImmunogenPurified antibody corresponding to Human IgA, Secretory.
      Clone4G10.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityBased on ELISA analysis, this antibody recognizes human IgA secretory subunit, with minimal or no cross-reaction human IgG or IgM.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human IgA.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G Purified
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by ELISA against Human IgA, Human IgG and Human IgM
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Packaging Information
      Material Size400 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MAC132 04053252978838

      Documentation

      Mouse Anti-Human IgA, Secretory Antibody, Clone 4G10.1 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Mouse Anti-Human IgA, Secretory Antibody, Clone 4G10.1 Analysenzertifikate

      TitelChargennummer
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 3167569
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - Q2434516 Q2434516
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - 3477004 3477004
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - 3574345 3574345
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - 3906475 3906475
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - 3977197 3977197
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - 4127492 4127492
      Mouse Anti-Human IgA, Secretory, Clone 4G10.1 - 4217496 4217496