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CBL496-25UG Mouse Anti-Human CD34 Monoclonal Antibody

Anti-CD34 Antibody, Class II, clone QBEND/10 is an antibody against CD34 Class II for use in FC, IP, IH, IH(P).

Mouse Anti-Human CD34 Monoclonal Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CD34 UniProt Number: P28906
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CBL496-25UG
25 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MkFC, IP, IHC, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL496-25UG
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMouse Anti-Human CD34 Monoclonal Antibody
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CD34 Antibody, Class II, clone QBEND/10 is an antibody against CD34 Class II for use in FC, IP, IH, IH(P).
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesIdentification of haemopoietic progenitor cells

      Studies into the control mechanisms of early haemopoiesis

      Purification of haemopoietic cells from, for example, FACS

      The antibody reacts with both frozen and fixed tissue sections from vascular endothelium and stromal fibroblasts

      Immunohistochemistry in parraffin sections: Pretreatment is HIER with citrate buffer, pH 6.0.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman endothelial vesicles
      CloneQBEND/10
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityThe antibody recognizes a heavily glycosylated transmembrane protein: gp 105-120 kDa. The antigen is expressed on immature human haemopoietic precursor cells, capillary endothelial cells and human myeloid cells in the following categories: subsets of CFU-GEMM and BFU-E, all CFU-GM, granulocyte precursors, monocytes, myeloid leukaemias. This antibody recognizes the class II epitope showing resistance to neuraminidase enzyme cleavage.

      KNOWN SPECIES CROSS REACTIVITY: Positive with rhesus monkey peripheral blood leucocytes in flow cytometry.

      FUSION PARTNER: NSO myeloma cell line
      IsotypeIgG1
      Species Reactivity
      • Human
      • Monkey
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM]
      Gene Symbol
      • CD34
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28906 # Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
      SIZE: 385 amino acids; 40716 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
      DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells.
      PTM: Highly glycosylated. & Phosphorylated on serine residues by PKC.
      DISEASE:SwissProt: P28906 # Abnormal CD34 expression in leukemogenesis.
      SIMILARITY: SwissProt: P28906 ## Belongs to the CD34 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in the United States.
      Quality AssuranceTested
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      CBL496-25UG 04054839350498